Benedetto Ghirlandaio's 'Portrait of a Young Woman,' 15th C CE, now in the collection of the Minneapolis Institute of Art.
From [artsmia.org](www.artsmia.org):
*'Benedetto was the youngest of the Ghirlandaio brothers, an established family workshop in late Quattrocento Florence. In the years 1486-1493 he sought new opportunities in France. His only documented work is a Nativity in the church of Aigueperse (Auvergne), where the painter worked for the governor Gilbert de Bourbon-Montpensier and his wife Chiara Gonzaga, daughter of Marquis Federico of Mantua. This portrait aligns so perfectly with the stylistic characteristics of the signed painting that its attribution to Benedetto cannot be doubted. There is no clue, however, as to the identity of the sitter...'*
More [here](https://collections.artsmia.org/art/1681/portrait-of-a-young-woman-benedetto-ghirlandaio)
More on 'cradling' for paintings on wood panels [here](https://en.wikipedia.org/wiki/Cradling_(paintings))