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Asset Overview
Neuraminidase is an enzyme of the avian influenza virus that catalyses the removal of sialic acid and subsequently allows the virus to exit cells and infect new ones. By mimicking the transition state of the enzyme-sialic acid complex, the drug oseltamivir inhibits neuraminidase and stops virus spread. The annotations reveal important interactions between the drug and the active site and critical residues whose absence often leads to drug resistance.
