Spironolactone bound to receptor.

Model of Mineralocorticoid receptor ligand-binding domain with spironolactone from an x-ray crystal stucture (3VHU) from the RSCB Protein Data Bank. Original data from “Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists”, Hasui, T., Matsunaga, N., Ora, T., Ohyabu, N., Nishigaki, N., Imura, Y., Igata, Y., Matsui, H., Motoyaji, T., Tanaka, T., Habuka, N., Sogabe, S., Ono, M., Siedem, C.S., Tang, T.P., Gauthier, C., De Meese, L.A., Boyd, S.A., Fukumoto, S., (**2011**) *J.Med.Chem*. *54*: 8616-8631.