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Molecular structure of the Human 20S proteasome complex with Bortezomib at 2.1 Angstrom.
The model was built using ChimeraX from X-ray diffraction data in the Protein Data Bank (PDB ID 5LF3).
DOI: 10.2210/pdb5LF3/pdb & https://www.cgl.ucsf.edu/chimerax/
‘The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.’ Schrader, J., Henneberg, F., Mata, R.A., Tittmann, K., Schneider, T.R., Stark, H., Bourenkov, G., Chari, A. (2016) Science 353: 594-598. PubMed: 27493187. DOI: 10.1126/science.aaf8993.
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